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Home Fish and Seafood

Salmon with Salsa Mayo Topping

4.36
/5
30 minutes mins
29 Comments
Jump to RecipePrint
By: Lalaine ManaloPosted: 04/19/2026Updated: 04/19/2026

This post may contain affiliate links. Please read my disclosure policy.

Baked Salmon with Salsa Mayo Topping is a quick and easy option for busy weeknight dinners, but fancy enough for company. The salsa and mayonnaise keep the fish unbelievably moist and flavorful for a meal that’s sure to impress.

baked salmon with salsa mayo topping on a baking sheet with cilantro in the background.

If you’re looking for a dinner meal that’s short on prep but packs amazing flavors, this baked salmon won’t disappoint. It requires minimum effort and very little tending, yet tastes as if you sweated in the kitchen for hours.

The secret to the moist and flavorful salmon? Mayonnaise! The fresh pico de gallo and mayonnaise add another layer of flavor and texture, and also act as a protective blanket that locks in the natural juices and keeps the fish from drying out during cooking.

Ingredient notes

salmon fillets, tomatoes, lime, cilantro, onions, mayonnaise, garlic, jalapeno.
  • This recipe uses salmon, but it’s also delicious with other fish like tilapia fillets or even other meats like this easy peasy cheesy mayo chicken breast.
  • If you want a bit more tang and fewer calories, substitute plain yogurt for the mayonnaise.
  • To skip extra prep and add a roasted flavor with mild heat, swap the pico de gallo for a can of diced green chilies, which are usually fire-roasted Anaheim or Hatch peppers.

Cooking instructions

preparing salmon fillets with salsa and mayonnaise topping.
  • Prepare the salsa by chopping all the vegetables. Make sure to deseed the tomatoes to prevent the salsa from getting too liquidy and soggy. Drain the salsa before mixing it with the mayonnaise to remove any pooled liquid.
  • Stir in the mayonnaise just when you’re ready to top the fish and bake, as the topping tends to water down over time and will slide off the fish.
  • Pat the fish dry with paper towels to remove excess moisture and help the mayo topping adhere better to the surface.

Cooking tip

Allow the salmon to rest for a few minutes after cooking for the juices to redistribute.

How to serve and store

serving baked salmon with a spatula from a baking sheet.
  • This baked salmon is delicious as a main entree for lunch or dinner. Pair it with cilantro-lime rice, which is perfect for soaking up any pan juices, and lemon-garlic broccoli and carrots, which you can conveniently roast in the oven at the same time.
  • Transfer leftovers to a container with a tight-fitting lid and refrigerate for up to 3 days.
  • For the best texture, reheat the fish in a 275°F oven, wrapped loosely in foil. Or reheat it in an air fryer at 300°F until warmed through.
  • Leftover salmon can also be enjoyed cold. Flake the fish and toss with your favorite salad greens or stir it with mayo for a quick sandwich filling.

More fish recipes

Sweet Chili Salmon with Garlic Spinach

Honey Garlic Salmon

Parmesan Crusted Tilapia

Blackened Tilapia Fish Tacos

Did you make this? Be sure to leave a review below and tag me @OnionRingsAndThings on Facebook and Instagram!

serving baked salmon with a spatula from a baking sheet.
4.36 from 14 votes

Salmon with Salsa Mayo Topping

Need a quick, foolproof weeknight dinner? This Baked Salmon is ready in under 30 minutes for an effortless, restaurant-quality meal at home! It features a Salsa Mayo topping that keeps the fillets incredibly moist, flaky, and packed with zesty flavor. The creamy crust locks in the juices and caramelizes perfectly in the oven.
Prep Time: 15 minutes mins
Cook Time: 15 minutes mins
Total Time: 30 minutes mins
Author: Lalaine Manalo
Course: Main Entree
Print Pin It Email Recipe
4 Servings

Ingredients

  • 4 (4 ounces each) salmon fillet
  • salt and pepper to taste
  • 2 Roma tomatoes seeded and diced
  • 1/2 small onion peeled and diced
  • 2 tablespoons fresh cilantro stemmed and chopped
  • 1/2 jalapeno seeded and minced
  • 1 clove garlic peeled and minced
  • 1 lime juiced
  • 1/2 cup mayonnaise

Instructions

  • Preheat oven to 400°F
  • In a bowl, combine tomatoes, onions, cilantro, jalapeno and lime juice. Season with salt and pepper to taste. Drain well. 
  • Add mayonnaise and stir to combine. 
  • Pat salmon dry. Season with salt and pepper to taste. Arrange in a single layer on an ungreased baking sheet.
  • Spoon mixture over salmon and spread to coat the top of fish thoroughly.
  • Bake for about 10 to 15 minutes or until the topping is lightly browned and the fish flakes easily with a fork.

Notes

  • Prepare the salsa by chopping all the vegetables. Make sure to deseed the tomatoes to prevent the salsa from getting too liquidy and soggy. Drain the salsa before mixing it with the mayonnaise to remove any pooled liquid.
  • Stir in the mayonnaise just when you’re ready to top the fish and bake, as the topping tends to water down over time and will slide off the fish.
  • Pat the fish dry with paper towels to remove excess moisture and help the mayo topping adhere better to the surface.
  • Let the baked salmon rest for a few minutes after cooking for the juices to redistribute.

Nutrition Information

Serving: 253g, Calories: 448kcal, Carbohydrates: 4g, Protein: 35g, Fat: 32g, Saturated Fat: 5g, Polyunsaturated Fat: 17g, Monounsaturated Fat: 8g, Trans Fat: 0.1g, Cholesterol: 105mg, Sodium: 255mg, Potassium: 950mg, Fiber: 1g, Sugar: 2g, Vitamin A: 385IU, Vitamin C: 12mg, Calcium: 35mg, Iron: 2mg

“This website provides approximate nutrition information for convenience and as a courtesy only. Nutrition data is gathered primarily from the USDA Food Composition Database, whenever available, or otherwise other online calculators.”

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About Lalaine Manalo

Welcome to Onion Rings and Things where you’ll find hundreds of comfort food recipes, crafts, and printables. Browse around and make something fun or tasty today! Read More

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Reader Interactions

4.36 from 14 votes (6 ratings without comment)

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Recipe Rating




  1. Leigh Anne Borders says

    Posted on 4/5/17 at 8:11 pm

    5 stars
    This looks like an amazing meal to make. My husband would enjoy this.

    Reply
    • Lalaine says

      Posted on 4/7/17 at 1:31 pm

      He’d love it for sure 🙂

      Reply
  2. Jenn Rollins says

    Posted on 4/4/17 at 12:43 pm

    I’ve never had salmon but this looks amazing. I am pinning it for later 🙂 Thanks for sharing!

    Reply
    • Lalaine says

      Posted on 4/5/17 at 8:30 pm

      I hope this will convince you to try salmon 🙂

      Reply
  3. Ruth I. says

    Posted on 4/4/17 at 6:30 am

    This looks so good! I have tried baking a similar recipe with dory and I think this is much better!

    Reply
  4. Coralie says

    Posted on 4/3/17 at 7:23 pm

    My hubby loves salmon. I will have to make this for him. It looks delicious.

    Reply
    • Lalaine says

      Posted on 4/3/17 at 7:25 pm

      I am sure he’d love this 🙂

      Reply
  5. Fatima Torres says

    Posted on 4/3/17 at 11:33 am

    This would be perfect for a weeknight. I have to pencil it in. Thank you for the suggestion.

    Reply
    • Lalaine says

      Posted on 4/3/17 at 7:25 pm

      You’re welcome. Enjoy!

      Reply
  6. Victoria Sconion says

    Posted on 4/3/17 at 8:49 am

    5 stars
    This looks so good! I want to try more Salmon even if my husband isn’t into it. I’m just bored with baked chicken. LOL

    Reply
    • Lalaine says

      Posted on 4/4/17 at 1:58 pm

      Mine is the same, too. He won’t touch fish but this salmon he can’t get enough of. 🙂

      Reply
  7. emma white says

    Posted on 4/3/17 at 3:18 am

    oh my this looks and sounds amazing and so much nicer than any I make mine looks bland and boring so I am sure going to give this a try

    Reply
  8. Elizabeth O. says

    Posted on 4/3/17 at 1:45 am

    I love Salmon, it’s a versatile ingredient and the more simple the recipe, the better it tastes! I love how easy this dish is to make. I’m definitely keeping the recipe.

    Reply
    • Lalaine says

      Posted on 6/28/17 at 4:26 pm

      Thanks a lot, Elizabeth!

      Reply
  9. Taty Pradilla says

    Posted on 4/2/17 at 9:21 pm

    Now this looks simply delicious!! I am going to have to make this for dinner ASAP!

    Reply
  10. Vishal Vashisht says

    Posted on 4/2/17 at 8:00 pm

    Nice recipe, but I will try it with some minor changes as I am a vegetarian and can’t have salmon. I would use Tofu instead and enjoy this tasty recipe.

    Reply
  11. Stacey Demrigian says

    Posted on 4/2/17 at 5:01 pm

    I am not a fish eater but that sounds absolutely delish!

    Reply
  12. Joely Smith says

    Posted on 4/2/17 at 4:15 pm

    5 stars
    We LOVE salmon! Thank you for a new way to serve it because honestly I was running out of ideas!

    Reply
    • Lalaine says

      Posted on 4/17/17 at 1:01 pm

      Enjoy!

      Reply
  13. Jeannette says

    Posted on 4/2/17 at 3:41 pm

    This looks seriously amazing! I’m a big salmon fan but always trying to find ways to jazz it up a little! This will be on the menu this week for sure!

    Reply
    • Lalaine says

      Posted on 6/28/17 at 4:27 pm

      Awesome, Jeannette!

      Reply
  14. Gábor says

    Posted on 4/2/17 at 3:32 pm

    4 stars
    Omg! I love salmon, I will try this as soon as Im at the ocean again to get fresh fish…

    Reply
    • Lalaine says

      Posted on 4/17/17 at 12:42 pm

      Lucky you 🙂

      Reply
  15. Gina says

    Posted on 7/29/13 at 5:55 pm

    I just made this and it was a huge hit even with my 3 kiddos ages 8, 4, and 2! I must confess though, I had some FRESH salsa from the grocery store instead of making some…I didn’t have the jalapenos. It really doesn’t get much easier. I will definitely be making this again! Thank you!

    Reply
    • Lalaine says

      Posted on 7/30/13 at 10:44 pm

      Hello Gina

      Thanks so much for trying the recipe and I am so glad you liked it.

      Reply
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